Mi médico me recetó éxtasis líquido, y así ando de cachondo con el GHB, cariño…
Enlace original: Drogoteca.com: Historias de Drogas y otras Delicadezas.
José Ortega y Gasset
Hace unos días, me enteré de una cosa curiosa que ahora me extraña no saber por otras vías, y haberlo conocido gracias a un neurólogo.
Hablando sobre algunas patologías relacionadas con el sueño, y su enfoque psiquiátrico (este neurólogo es a la vez un psiquiatra) versus su enfoque fisiológico básicamente dentro de la neurología, me comentó que una patología poco común (alrededor de 3 casos por cada 10.000 personas) como es la cataplejia o cataplexia, tenía un nuevo fármaco curioso.
La cataplejia es un trastorno por el cuál la persona sufre episodios de perdida total del tono muscular, con la consiguiente caída y bofetón contra el suelo si no está en la cama o sentado en algún sitio que le sostenga. Suele ir asociada a un trastorno también infrecuente como la narcolepsia, el cuál provoca súbitos ataques de sueño, normalmente incontrolable y repentino, en el que uno se puede quedar dormido a mitad de una frase sin enterarse.
Por suerte, es también otro de los trastornos poco frecuentes. Ambos trastornos son considerados enfermedades huérfanas, debido a la baja incidencia en la población que tienen, y por lo tanto la investigación sobre ellos, es casi inexistente, y los tratamientos farmacológicos suelen derivarse de los que se usan para otro tipo de enfermedades (digamos que son reaprovechados).
Por ejemplo, el metilfenidato (Rubifen) que se usa para las personas diagnosticadas con trastorno por déficit de atención con hiperactividad, es el fármaco que se usa para los narcolépticos, en España. Y en los USA, las anfetaminas del Adderall o la metanfetamina del Desoxyn, que parecen más adecuadas para un problema así y una solución puntual, pero que en España no se recetan porque fueron eliminadas del sistema de salud hace años.
No hay un desarrollo de investigaciones específico para esos trastornos con tan poca gente sufriéndolos: no son rentables para la industria farmacéutica que es la que finalmente financia los estudios en una u otra dirección.
Y en ese contexto se ha colado una terrible droga… cuando la toman los adultos porque les sale del mismo sitio que el apetito, y no porque se la manda un comeflores (va por tí, campeón) con bata blanca y sueldo engordado con caricias de las farmacéuticas.
Charlando me comentó: “Pues ahora, para la cataplejia, ya tenemos un medicamento. Es un primo del éxtasis líquido.”
En el acto se me pusieron las orejas de punta (virtualmente).
Y me puse a investigar un poquito. No fue nada complicado.
Y así pude decirle: “Oye, que eso no es un primo del éxtasis líquido, es el GHB o éxtasis líquido!!”
El GHB lo tienen los hospitales bajo el nombre comercial de Xyrem.
El Ácido Gamma Hidroxi Butírico, o en su forma salina, Gamma Hidroxi Butirato (de sodio o de potasio), que hasta ahora era el infame éxtasis líquido, droga con fama de provocar los mismos efectos que el alcohol, pero en versión más sexual y libidinosa.
Alguna persona, con una experiencia impresionante en drogas, me contaba que era posiblemente el único afrodisíaco que conocía (para él), ya que le ponía cachondísimo.
Y en honor a la verdad, hay que decir que el GHB es también un neurotransmisor que se encuentra de forma natural en el cuerpo humano.
Más simple que el mecanismo de un chupete.¿Y ahora se lo dan a personas con un trastorno del sueño?
¿Pero no hemos quedado en que era una droga mala mala malísimamente mala?
Aprobado en toda Europa hacia el año 2003 y con licencia para ser comercializado en el año 2005, parece que ha sido hace relativamente muy poco que se le ha dado paso al uso hospitalario en España, ya que no hay muchos médicos que tengan conocimiento de su existencia siquiera. El éxtasis líquido, ha encontrado un hueco en la farmacopea para una enfermedad que no tenía ningún fármaco específico.
¿Que hace el GHB con la gente que tiene cataplejia?
Pues como la cataplejia va acompañada de un sueño fragmentado, desestructurado, sin unas correctas fases REM y noREM (o como las llaman ahora en castellano, MOR y noMOR, aunque suene como Chiquito de la Calzada), se han dado cuenta de que el GHB hace dormir…. y hace dormir bien.
Consigue que el paciente duerma unas siestas reconfortantes, y que realmente le hagan descansar su cerebro, para evitar que durante el día tenga accesos salvajes de sueño y de pérdida del tono muscular.
Lo que me parece increíble, son las enormes dosis que se prescriben para uso terapéutico.
Las dosis para uso lúdico, según un sitio respetable y serio como Erowid, son de alrededor de 1 gramo para una dosis suave, 2 para una media, y 3 para una fuerte, y tiene una serie de advertencias que no se suelen observar cuando expresan la dosificación de otras drogas, sobre el riesgo de coma, y el riesgo de muerte.
También advierten del riesgo de adición, ya que aumenta la producción de dopamina, y advierten que tomarlo demasiado a menudo puede dar problemas. Cuentan casos de personas que, tras meses de consumo diario, tiene problemas como ir escuchando campanas… y no saber donde (porque no las hay en realidad).
Y en terapéutica las dosis oscilan entre 4’5 gramos y 9 gramos al día…!!! Al parecer van en dos o tres dosis, comenzando con una dosis de 2’5 gramos… vamos, que si no te duermes, vas a enganchar una borrachera salidorra de lo más curioso.
No me acabo de explicar que con todo lo que se ha dicho del GHB y sus peligros, ahora resulte que se pauta de esa forma, para un consumo que como poco, dura varias semanas. Y ya se sabe lo que ocurre con ciertas medicaciones, como las benzodiacepinas y lo inductores del sueño, que son para tratamientos puntuales normalmente, pero acaban siendo un compañero de viaje durante años o para siempre.
¿Vá a resultar que la gente que ha estado haciendo un uso lúdico del GHB, no se excedían tanto? ¿Que su consumo esporádico se muestra como poco o nada dañino en vista de que alguien pueda consumir 9 gramos en 3 horas para dormir?
Eso sí, los responsables farmacéuticos, y la clase médica, han tenido el detalle de no alarmar al usuario cataplejico… y en lugar de decirles que les van a dar éxtasis líquido o GHB, se le ha dado otro nombre.
Oxibato Sódico suena infinitamente más respetable, como principio áctivo. Si no, imagínese el lector a una señora madre diciendole a su hijo: “Niño, acércame el éxtasis líquido que me voy a la cama, anda”.
Y como nombre comercial, Xyrem. Nada de éxtasis ni nada de GHB.
Pero con todo y con eso, ahí está la química, tan terca como siempre, diciendo que son exactamente la misma molécula. Qué cosas…
Al menos, en un curioso gesto, tienen la decencia de decir la verdad sobre su mecanismo de acción: NO TIENEN NI IDEA DE COMO FUNCIONA. En los propios prospectos y en los documentos del estudio que llevo al GHB a ser aprobado, lo dicen sin tonterías:
“¿Cómo actúa Xyrem?“
El principio activo de Xyrem, el oxibato de sodio, es un depresor del sistema nervioso central. No se conoce su mecanismo exacto de actuación, pero se cree que se une a moléculas receptoras específicas en la superficie de determinadas células en el cerebro.
Esto provoca cambios en la actividad cerebral, promoviendo el sueño de onda lenta (delta) y consolidando el sueño nocturno.
Si se toma antes de acostarse, Xyrem refuerza el sueño profundo y aumenta el tiempo de sueño nocturno, reduciendo, al mismo tiempo, el número de periodos de sueño durante el día, lo cual mejora los síntomas de narcolepsia.“
Los efectos secundarios son de lo más variopinto, y tiene algunas contraindicaciones absolutas, como un trastorno enzimatico por el cual hay un fallo en la metabolización de este y otros compuestos (normalmente alcoholes, o compuestos con un grupo OH) por una ausencia de la succinato-semialdehido-dehidrogenasa, o pacientes que tomen barbitúricos u opiáceos, zolpidem o modafinilo.
Así que esa sustancia, que hace unos años a nadie interesaba, luego interesó a los culturistas, luego al mercado lúdico, y con su prohibición se hizo famosa y pasó a tenerla disponible cualquiera excepto un médico, ha vuelto a poder ser usada para ese trastorno y quien sabe si acabará siendo igual para otros, otros trastornos, y también otros fármacos….. Lo digo pensando en el que más posibilidades terapéuticas tiene: la MDMA, éxtasis o cristal para la mayoría de las personas, y que NADA TIENE QUE VER CON EL GHB, o el “snob” oxibato sódico-Xyrem.
Es una buena noticia, que la propia Agencia Europea del Medicamento, se ha encargado de justificar… no siendo que le dé a alguien por pensar que las drogas, que son todas malas y peligrosas, puedan tener algún uso interesante que no sea el de provocar orgías de sexo y desenfreno.
Y se han molestado en explicar cómo se les ha ocurrido semejante cosa (y aconsejando una dosis mínima bastante generosa): “¿Por qué se ha aprobado Xyrem?
El Comité de Medicamentos de Uso Humano (CHMP) decidió que los beneficios de Xyrem son mayores que sus riesgos en el tratamiento de la narcolepsia con cataplejía en pacientes adultos.
Aunque la dosis de 9 g resultó ser la más efectiva, fue también la que más efectos secundarios tenía, por lo que el comité recomendó una dosis inicial de 4,5 g diarios.
Como la dosis efectiva es cercana a la dosis a la que los efectos secundarios son graves, los aumentos en la dosis deben realizarse con todo rigor y bajo la supervisión de un médico especialista en el tratamiento de trastornos del sueño.
El Comité recomendó autorizar la comercialización de Xyrem.”
Ya sabéis, si tenéis problemas de sueño, pero de los gordos, tal vez ha llegado el momento de que empecéis a medicaros con éxtasis líquido o GHB, siempre con la recomendación de un licenciado y tras una concienzuda revisión de tus costumbres, no siendo que la uses como droga…
…eso sí que no.
Extraído de: Drogoteca.com: Historias de Drogas y otras Delicadezas.
74 comentaris
és curiós l’article, si més no curiós.
Lo trist és que no sona a res de nou ni extrany (el mateix que la ketamina, l’LSD, la mmarihuana…), és lo que hi ha.
M’encanta la lògica!
jajaja brutal!
diculpar por no escribir en catalan ,soy basco frances,pues que curioso que aqui en francia es parecido,a los travelers que vivimos en camiones ,organizamos fiestas con nuestro tipico look, como no saben que darte para desenganchar la keta ,,te dan lo mismo para recuperar un ritmo normal para dormir,,la gente a descubierto un nuevo bisnes,el narco oficial el gobierno !!!!!!!!! gracias sarco nuestro presidente !!!!!!! lo peor es que lo saben,,,,,,,,merci a tous
Disculpad k yo tmpko able en catalá pero esk nose, xk sy d c.real.. xD
Solo t keria dar las gracias x esta informacion, xq sy narcolepsico y mi neurologo
m keria recetar xyrem, pero m enseño dos folios d contraindicaciones y m dijo k m lo pensara, y esty viendo ade+ d td lo k as dixo, k la mayoria ya m sonaba, k aun sta en fase d pruebas, y k no conocen los verdaderos efectos en menores d 18 y yo vy a cumpli r 17 pronto, asik m parece k paso d meterme extasis en el cuerpo, prefiero segir cm esty, aunk tenga k aguantar las cataplejias, y otras pastillas…
Gracias x la informacion!
Es curios observar com una persona que no te ni puta idea de el que es la cataplexia, s’atreveix a despotricar sobre l’unica solucio que de moment tenim els que la sofrim.
Abans de obrir la boca, t’auries d’informar del que es la narcolepsia-cataplexia, i despres parlem del que vulguis.
Abans de treure aquest medicament, per que es un medicament per tractar una enfermetat, hauries d’enterarte de quins somt els beneficis d’aquest medicament.
Un apunt : xyrem no es comercialitza. Nomes es pot aconseguir a traves de la faarmacia d’un hospital.
Yo sí hablo y escribo catalá.
També soc especialista, y de sono.
He estudiado en BCN -Espanya, EEUU, y otros países y tengo pacientes con narcolepsia.
Como sí puedo hablar porque sé y mucho, les digo que los médicos nos equivocamos y bastante a veces ponemos sobre la balanza lo que llamamos costo- beneficio y con buena intención usamos drogas que más tarde lamentamos. Malapraxis???, iatrogenia, acierto-error, no lo sé.
Felicito a quien escribe el artículo porque se tomó la molestia de investigar farmacocinética, dosis, efectos adversos y hasta el hipnograma de una polisomnografía. Si alguno de vosaltres , pudiera ver a los jóvenes drogados con éxtasis líquido y lo que les sucede bajo su efecto, se lo pensaria y buscaría asociación de drogas, para tratar la narcolepsia.
Si logran reducir el sueño REM, si usan terapia conductual para hacer siestas programadas, junto con otras drogas que eliminan la cataplejía que es uno de los componentes de la tétrada de la narcolepsia probablemente no necesiten el oxibato de sodio, lindo nombre para el GHB.
Hay tratamientos alternativos y se adecúan a cada paciente según predomine un síntoma u otro.
Sean cuidadosos, e investiguen , busquen más de una opinión, aún hay que aprender mucho.
Moltes graciés,
Bona nit,
A tots els que escribiu, només us recriminu que no tingueu present que els que som narcolèptics som molt sensibles als vostres comentaris i, sobint, busquem pendre decisions sobre els fàrmacs a través de pàgines com aquesta.
Jo vaig començar a tractar-me amb Rubifren (vaig deixar-ho de l’ansietat que em generava), vaig passar-me al modiodal (funciona un xic, però el mal de cap i irritabilitat no compensen). Ara el meu neuroleg m’ha dit que “SI VULL” probi en XYREM i, la veritat, vaig perdut.
Però, és tanta la necessitat de millorar, de tornar a ser el d’abans que potser el començaré a pendre…..
Hola, soy narcoleptica y como ya ha dixo algu es cierto hay k vivir en el pellejo d cada uno para ver de lo k somos capaces.
Yo nunca h tomado drogas ni alcohol ni nada, pero mi vida cada vez estaba mas destrozada y yo tambien. Empece con rubifen despues modiadal, luego siguio concentra 36 y 52 y mi vida a peor, los k tenemos esta enfermedad el xirem, extaxis o como lo krais llamar no nos hace el mismo efecto k a una persona normal, no se xk pero es cierto, comprobadlo lo tenemos facil teniendo el medicamento o droga en casa.
La verdad esk es una mierda este medicamento entre otras cosas xk a las 3 h mas o menos tenemos k tomar la segunda dosis pero lo k kiere cualkier persona es calidad de vida y si tengo k ser conejillo de indias sere por un poco d vida digna, las cataplejaas no se van el sueño tampoco pero si puedo apaliarla un poco!!! x lo menos tengo la esperanza de k mi vida mejore lo demas tampoco funciona asi que que diferencia hay entre unos y otros medicamentos? Os lo dire, este x lo menos , no lo pagamos k todos suben de 50€ minimo yo x lo menos 120€ al mes en medicamento y ahora son 12€ en un protector de estomago
SERGI
Yo h tomado de todos y la verdad xyrem es parecido lo difícil es despertarse al rato, pero a mi no me esta llendo mal h empezado hace casi un mes y no tengo tantas cataplejias s m han reducido a la mitad, somos conejillos de india con este y con todos los medicamentos k vallan saliendo yo h empezado con (1.1x 2dosis) hasta el lunes y ahora (2.25x 2) xk somos pocos los k padecemos esta enfermedad y k asi siga siendo, xk no s lo deseo a nadie.
Asi k d ti depende, la verdad, todos son drogas rubifen , modiodal , concerta, todos ,todos.
Mas la calidad de vida o no, es decisión tuya, eso no kiere decir k nos libremos d los efectos secundarios k son muxos el d xyrem hay muchos mas.
Suerte decidas lo k decidas y dulces sueños.
Hola ,soy Narcoleptica y ayer me tome mi primera dosis de Xirem (2’25 gr). 15 minutos despues de tomarlo me quede dormida.Desperte dos horas mas tarde sin ningun sintoma .Gracias por tu articulo,me ha servido de mucho.
Perdoade por non escribir catalan.Son Galega.
Siento mucho no escribir en catalan, no se . posiblemente ninguno de ustedes se halla partido la cara contra el suelo por culpa del sindrone de narcolepsia con catalepsia, o se halla roto varias costillas al caerse o alguna pierna o brazo, pero como los que como yo sufrimos de ese trastorno y tenemos el cuerpo hecho una virria (mierda) el XYREM de momento es lo que mejor funciona. Para el que dice que es especialista y ademas del sueño, tio no tienes ni idea, una cosa es que te cuenten algo en tu consulta y otra muy difenrente que tu lo tengas, por ejemplo, yo no podia ir al cine por que me quedaba dormido, no podia leer mas de dos paginas de un libro o como ejemplo mas simple no podia follar por que tenia catalepsias cuando lo estaba haciendo. Lo que intento decir es que no hableis de cosas de las que no teneis ni idea, por dios.
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Mi médico me recetó éxtasis lÃquido, y asà ando de cachondo con el GHB, cariño | Be Underground…
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Mi médico me recetó éxtasis lÃquido, y asà ando de cachondo con el GHB, cariño | Be Underground…
Hola buenas!!!
Tengo un problema, espero que me podáis ayudar. .. tengo una amiga que lleva tiempo tomando ghb para poder dormir mejor… pero ahora intenta dejarlo y no puede… le dan espasmos, temblores, le entra el mono de hacerse más. .. le cambia el humor y no para de pensar en hacerse más. .. intenta dejarlo, pero acaba haciéndose de lo mal que lo pasa, por sonidos, temblores, ansiedad. …
POR FAVOR NECESITAMOS AYUDA, ALGUIEN QUÉ NOS PUEDA ACONSEJAR DE COMO POR DE DEJAR DE TOMAR ESTA MIERDA
… Se que lo mejor es un médico, pero hasta dentro de 2 semanas no tiene cita y lo está pasando muy mal.
Agradecería que alguien nos pudiera ayudar por favor….
Gracias por adelantado, saludos!
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